Title | 2,000 Steps/Day Does Not Fully Protect Skeletal Muscle Health in Older Adults During Bed Rest. |
Publication Type | Journal Article |
Year of Publication | 2019 |
Authors | Arentson-Lantz E, Galvan E, Wacher A, Fry CS, Paddon-Jones D |
Journal | J Aging Phys Act |
Volume | 27 |
Issue | 2 |
Pagination | 191-197 |
Date Published | 2019 04 01 |
ISSN | 1543-267X |
Keywords | Aged, Bed Rest, Female, Healthy Volunteers, Humans, Insulin Resistance, Male, Muscle, Skeletal, Sarcopenia, Walking |
Abstract | Physical activity in an inpatient setting is often limited to brief periods of walking. For healthy adults, public health agencies recommend a minimum of 150 min/week of moderate-intensity exercise. The authors sought to determine if meeting this activity threshold, in the absence of incidental activities of daily living, could protect skeletal muscle health during bed rest. Healthy older adults (68 ± 2 years) were randomized to 7-day bed rest with (STEP, n = 7) or without (CON, n = 10) a 2,000 steps/day intervention. Performing 2018 ± 4 steps/day did not prevent the loss of lean leg mass and had no beneficial effect on aerobic capacity, strength, or muscle fiber volume. However, the insulin response to an oral glucose challenge was preserved. Performing a block of 2,000 steps/day, in the absence of incidental activities of daily living, was insufficient to fully counter the catabolic effects of bed rest in healthy older adults. |
DOI | 10.1123/japa.2018-0093 |
Alternate Journal | J Aging Phys Act |
PubMed ID | 29989486 |
PubMed Central ID | PMC6710835 |
Grant List | P30 AG024832 / AG / NIA NIH HHS / United States R01 NR012973 / NR / NINR NIH HHS / United States UL1 RR029876 / RR / NCRR NIH HHS / United States UL1 TR000071 / TR / NCATS NIH HHS / United States UL1 TR001439 / TR / NCATS NIH HHS / United States |