Title | Effects of omega-3 fatty acid supplementation on lipid levels in endstage renal disease patients. |
Publication Type | Journal Article |
Year of Publication | 2009 |
Authors | Bowden RG, Fry JL, Wilson RL, Gentile M |
Journal | J Ren Nutr |
Volume | 19 |
Issue | 4 |
Pagination | 259-66 |
Date Published | 2009 Jul |
ISSN | 1532-8503 |
Keywords | Adult, Aged, Cardiovascular Diseases, Cholesterol, HDL, Cholesterol, LDL, Dietary Supplements, Double-Blind Method, Fatty Acids, Omega-3, Female, Humans, Kidney Failure, Chronic, Lipids, Male, Middle Aged, Placebos, Risk Factors |
Abstract | OBJECTIVE: Our purpose was to determine if over-the-counter fish oil improves the cardiovascular-disease risk profile of endstage renal disease patients. DESIGN: This study used a double-blind, permuted-block, randomized, placebo-controlled design. The experimental intervention consisted of fish-oil concentrate supplementation, whereas corn-oil capsules were used as a control. Compliance follow-ups were performed 3 times per week. SETTING: Patients of Central Texas Nephrology Associates clinics were eligible for this study. PATIENTS: Exclusion criteria comprised a life-expectancy of less than 6 months, pregnancy, a history of hemodialysis or medication noncompliance, or age below 18 years. The final sample size was 87 patients. The attrition rate was 9%. INTERVENTION: Participants in the experimental group consumed six 1-g soft-gel capsules of fish-oil concentrate each day for 6 months. The control group consumed corn-oil capsules, following the same protocol. Venous blood samples were acquired before and after the intervention. MAIN OUTCOME MEASURE: We assessed a number of serum lipid indicators. RESULTS: There were significant supplement/time interactions in low-density lipoprotein cholesterol (LDL) levels (P = .0001) and LDL particle number (P = .0001). Repeated-measures analysis of variance revealed significant time trends in high-density lipoprotein cholesterol (P = .012) and LDL (P = .001). High-density lipoprotein cholesterol levels significantly decreased in the control group, and increased in the fish-oil group, at 6 months, and LDL levels increased significantly in both groups. CONCLUSIONS: The analysis indicates mixed results with respect to cardiovascular disease risk. Further research is needed to assess the benefits of an over-the-counter fish-oil supplement in the renal population. |
DOI | 10.1053/j.jrn.2009.01.030 |
Alternate Journal | J Ren Nutr |
PubMed ID | 19539180 |