Title | Quadratic Association Between Corticomotor and Spinal-Reflexive Excitability and Self-Reported Disability in Participants With Chronic Ankle Instability. |
Publication Type | Journal Article |
Year of Publication | 2016 |
Authors | Harkey M, McLeod MM, Terada M, Gribble PA, Pietrosimone BG |
Journal | J Sport Rehabil |
Volume | 25 |
Issue | 2 |
Pagination | 137-45 |
Date Published | 2016 May |
ISSN | 1543-3072 |
Keywords | Activities of Daily Living, Adult, Ankle Joint, Chronic Disease, Cortical Excitability, Disability Evaluation, Female, Humans, Joint Instability, Linear Models, Male, Self Report, Transcranial Magnetic Stimulation, Young Adult |
Abstract | CONTEXT: Spinal-reflexive and corticomotor excitability may have a critical role in altering muscle function needed to stabilize the ankle in people with chronic ankle instability (CAI). OBJECTIVE: To determine the association between self-reported disability and both spinal-reflexive and corticomotor excitability in people with CAI. DESIGN: Descriptive laboratory study. SETTING: Research laboratory. PARTICIPANTS: 30 participants with CAI. MAIN OUTCOME MEASURES: Soleus spinal-reflexive excitability was measured with normalized Hoffmann reflexes (H:M ratio), and corticomotor excitability was measured with transcranial magnetic stimulation and quantified by normalized motor-evoked-potential (MEP) amplitudes at 120% of active motor threshold (120%MEP). Self-reported disability was quantified with the activities-of-daily-living and sport subscales of the Foot and Ankle Ability Measure (FAAM-ADL and FAAM-S). Separate linear Pearson product-moment correlations and nonlinear quadratic correlations were used to determine associations between the neural-excitability and disability variables. RESULTS: Thirty participants were included in the spinal-reflexive-excitability analysis, while only 19 were included in the corticomotor analysis. There was a significant, weak linear association between H:M ratio and FAAM-ADL (R = .39, P = .03) and a nonsignificant, weak linear association between H:M ratio and FAAM-S (R = .36, P = .06). There were significant, moderate quadratic associations between H:M ratio and both FAAM-ADL (R = .48, P = .03) and FAAM-S (R = .50, P = .02). There was a significant, moderate linear association between 120%MEP and FAAM-ADL (R = -.48, P = .04) and a nonsignificant, moderate negative linear association between FAAM-S (R = -.42, P = .07). There was a significant, moderate quadratic association between 120%MEP and FAAM-ADL (R = .57, P = .046) and a significant, strong quadratic correlation between 120%MEP and FAAM-S (R = .71, P = .004). CONCLUSIONS: There are significant quadratic associations between self-reported disability and both spinal-reflexive and corticomotor excitability of the soleus. CAI participants with low or high neural excitability present with lower function. |
DOI | |
Alternate Journal | J Sport Rehabil |
PubMed ID | 25759960 |