Title | Muscle Fiber Splitting Is a Physiological Response to Extreme Loading in Animals. |
Publication Type | Journal Article |
Year of Publication | 2019 |
Authors | Murach KA, Dungan CM, Peterson CA, McCarthy JJ |
Journal | Exerc Sport Sci Rev |
Volume | 47 |
Issue | 2 |
Pagination | 108-115 |
Date Published | 2019 04 |
ISSN | 1538-3008 |
Keywords | Animals, Humans, Models, Animal, Muscle Fibers, Skeletal, Muscle, Skeletal, Resistance Training, Stress, Physiological |
Abstract | Skeletal muscle fiber branching and splitting typically is associated with damage and regeneration and is considered pathological when observed during loading-induced hypertrophy. We hypothesize that fiber splitting is a nonpathological component of extreme loading and hypertrophy, which is primarily supported by evidence in animals, and propose that the mechanisms and consequences of fiber splitting deserve further exploration. |
DOI | 10.1249/JES.0000000000000181 |
Alternate Journal | Exerc Sport Sci Rev |
PubMed ID | 30640746 |
PubMed Central ID | PMC6422761 |
Grant List | F32 AR071753 / AR / NIAMS NIH HHS / United States R01 AR060701 / AR / NIAMS NIH HHS / United States |