Title | A prospective analysis of factors associated with decreased physical activity in patients with cirrhosis undergoing transplant evaluation. |
Publication Type | Journal Article |
Year of Publication | 2015 |
Authors | Cruz AChristina, Vilchez V, Kim S, Barnes B, Ravinuthala A, Zanni A, Galuppo R, Sourianarayanane A, Patel T, Maynard E, Shah MB, Daily MF, Uhl TL, Esser K, Gedaly R |
Journal | Clin Transplant |
Volume | 29 |
Issue | 11 |
Pagination | 958-64 |
Date Published | 2015 Nov |
ISSN | 1399-0012 |
Keywords | Adult, Aged, Case-Control Studies, End Stage Liver Disease, Female, Follow-Up Studies, Hand Strength, Humans, Liver Cirrhosis, Liver Transplantation, Male, Middle Aged, Motor Activity, Prognosis, Prospective Studies, Risk Factors, Severity of Illness Index |
Abstract | BACKGROUND: Physical activity (PA) has been associated with improved recovery time after transplantation. Handgrip strength has been related to post-transplant outcomes. AIM: To evaluate predictors of PA and grip strength in patients with cirrhosis undergoing liver transplant evaluation. METHODS: Single-center, prospective analysis. RESULTS: One hundred patients were evaluated (54% male, mean age 53 ± 9). Common etiologies of liver disease were non-alcoholic steatohepatitis (27%), hepatitis C (22%) and alcoholic liver disease (21%). Mean model of end-stage liver disease (MELD) score was 13.5. Forty-one percent had a history of smoking. Ninety-three patients completed the International Physical Activity Questionnaire (IPAQ). The median total PA score was 33 metabolic equivalent (MET)-min/wk. The mean total grip strength was 62.1 ± 22 lb. Total grip strength was found to be an independent predictor of low-moderate PA (OR 4.7, 95% CI 1.4-16.2, p = 0.038), and smoking was the only significant factor associated with reduced grip strength (OR 3.4, 95% CI 1.4-8, p = 0.005). CONCLUSIONS: Patients with end-stage liver disease undergoing liver transplant evaluation have reduced total PA by IPAQ. Total grip strength was found to be a significant predictor of low-moderate PA in patients with cirrhosis. Smoking is a risk factor for reduced grip strength, an important indicator of muscle wasting in cirrhotics. |
DOI | 10.1111/ctr.12602 |
Alternate Journal | Clin Transplant |
PubMed ID | 26263921 |
PubMed Central ID | PMC4624476 |
Grant List | R01 AR061939 / AR / NIAMS NIH HHS / United States |