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Muscle Biology
Charlotte Peterson, PhD
Nicotinomide Riboside With and Without Resveratrol to Improve Functioning in Peripheral Artery Disease: The NICE Trial
Northwestern University (American Heart Association)
The goal of this study is to determine whether a novel intervention, nicotinamide riboside (NR), with and without resveratrol, improves walking performance in people with peripheral artery disease by improving calf muscle mitochondrial dysfunction.
Project Period: 07/01/2020 to 03/31/2022
Total Value: $17,467
Jean Fry, PhD, RDN
Diversity Supplement: Mechanistic Assessment of Blood Flow Restricted Training for an ACL Injury
National Institute of Arthritis, Musculoskeletal & Skin Diseases
The goal of this study is to determine whether insufficient dietary vitamin D intake or status exacerbates expected decrements in type 2a fiber cross sectional area associated with ACL tear.
Project Period: 09/25/2020 to 06/30/2022
Total Value - $274,182
Esther Dupont-Versteegden, PhD & Tim Butterfield, PhD, ATC
Mechanisms underlying local and systemic effects of massage
NIH/National Center for Complementary & Integrative Health
The goal of this study is to determine anabolic effects of massage in human muscle, and to identify whether extracellular vesicles released with massage are candidates for beneficial effects of this mechanotherapy on muscle as well as other organs.
Project Period: 08/01/2020 to 07/31/2022
Total Award: $440,151
Christopher Fry, PhD
STTR: Preclinical Studies to Validate the Efficacy of Novel Mechanism-of-Action Small Molecule Inhibitors to Treat Duchenne Muscular Dystrophy
NIH/Ridgeline Therapeutics
The purpose of UK’s role in this project is to complete repeat oral-dosing and chow-admixed drug pharmacokinetic studies to validate systemic exposures and route of drug delivery for RLT-72484 and complete in vivo efficacy studies using translationally-relevant complementary DMD mouse models.
Project Period: 02/01/2020 to 08/31/2021
Total Award: $120,543
Christopher Fry, PhD
SBIR: Dose-ranging safety and efficacy studies to advance novel mechanism-of-action drug candidates to reverse age-related muscle degeneration
NIH/Ridgeline Therapeutics
The objective of this Phase I project is to demonstrate proof-of-principal and safety for novel mechanism-of-action therapeutic candidates using translationally relevant muscle growth/function models in aged animals and appropriate in vivo safety models.
Project Period: 07/01/2019 to 03/31/2021
Total Award: $91,014
Charlotte Peterson, PhD and John McCarthy, PhD (College of Medicine)
Alzheimer’s Disease Supplement to Exercise-Induced Skeletal Muscle Exosomes Promote Adipocyte Lipolysis
National Institute on Aging
The purpose of the supplement is to extend the analysis of mechanisms underlying the benefits of physical activity on the Alzheimer’s disease brain.
Project Period: 08/01/2019 to 07/31/2023
Total Award: $382,000
Christopher Fry, PhD
Development of NNMT Inhibitors as Novel Interventions to Activate Quiescent Muscle Stem Cells and Improve Age-related Muscle Degeneration
University of Texas Medical Branch at Galveston (National Institute on Aging)
The purpose of this project is to validate the novel small molecule NNMT inhibitors as safe and effective therapeutic leads to increase muscle regeneration and function in aged animals.
Project Period: 07/01/2019 to 01/31/2021
Total Award: $39,382
Charlotte Peterson, PhD and John McCarthy, PhD (College of Medicine)
Exercise-induced Skeletal Muscle Exosomes Promote Adipocyte Lipolysis
National Institute of Diabetes & Digestive & Kidney Diseases
This study investigates the mechanism through which resistance exercise causes skeletal muscle to communicate with adipose tissue to promote the burning of fat. The findings from this study are expected to provide the fundamental knowledge necessary to develop a novel therapeutic strategy to treat obesity using exosomal miR-1 delivery to adipose tissue.
Project Period: 09/19/2018 to 07/31/2023
Total Award: $1,945,714
Charlotte Peterson, PhD
The Glenn Award for Research in Biological Mechanisms of Aging
Glenn Foundation for Medical Research
The Glenn Award is a one-time cash infusion of $60,000 to augment the research in Dr. Peterson's laboratory that furthers the mission of the Foundation, which is “to extend the healthy years of life through research on mechanisms of biology that govern normal human aging and its related physiological decline, with the objective of translating research into interventions that will extend healthspan with lifespan.”
Project Period: 09/18/2018 to 09/18/2021
Total Award: $60,000
Esther Dupont-Versteegden, PhD & Tim Butterfield, PhD, ATC
Administrative Supplement: Mechanisms Underlying Anabolic Effects of Cyclic Compressive Loading in Muscle
This study addresses the hypothesis that male and female rats will exhibit a different anabolic effect to cyclic compressive loading, a massage mimetic, during atrophy and during regrowth after atrophy with aging.
Sponsor: National Center for Complementary & Integrative Health
Project Period: 09/12/2018 to 03/31/2022
Total Award: $99,450
Charlotte Peterson, PhD
Intermittent Pneumatic Compression for Disability Reversal in PAD: The INTERCEDE Study
Northwestern University (National Institute on Aging)
In people with Peripheral Artery Disease, we will determine whether treatment with intermittent pneumatic compressive augments the benefits of exercise, whether intermittent pneumatic compression alone improves walking performance compared to control, and whether the benefits of intermittent pneumatic compression are durable.
Project Period: 08/01/2018 to 04/30/2023
Total Award: $122,881
Christopher Fry, PhD
Myostatin Alters Muscle Composition as the Result of an ACL Injury
National Institute of Arthritis & Musculoskeletal & Skin Diseases
This study is to determine the time course of deleterious changes within the injured limb muscle and identify myostatin as integral in the etiology of protracted muscle weakness in individuals following an ACL tear and reconstruction.
Project Period: 03/26/2018 to 02/28/2023
Total Award: $2,186,072
Esther Dupont-Versteegden, PhD & Tim Butterfield, PhD, ATC
Mechanisms Underlying Anabolic Effects of Cyclic Compressive Loading in Muscle
National Center for Complementary & Integrative Health
This study explores the use of massage as an intervention to decrease muscle atrophy during disuse and to increase the ability to regrow muscle size after inactivity and will determine underlying mechanisms underlying these beneficial effects.
Project Period: 04/01/2017 to 03/31/2022
Total Award: $2,122,436
Charlotte Peterson, PhD
Improve PAD PERformance with METformin: The PERMET Trial
Northwestern University (National Heart, Lung and Blood Institute)
This study explores if Metformin, an inexpensive, widely available, and well-tolerated medication for Type 2 diabetes, will improve walking ability and prevent mobility loss in people with PAD.
Project Period: 12/09/2016 to 11/30/2021
Total Award: $121,031
Charlotte Peterson, PhD
Assessing the Health Effects of Blast Injuries and Embedded Metal Fragments
University of Maryland at Baltimore (U.S. Department of Defense)
The primary objective of this project is to determine if the adverse health effects caused by embedded metal fragments can be predicted by changes in gene and microRNA expression in the surrounding muscle, urine or serum. The identification of such an early biomarker has important clinical implications in providing treatment to wounded warriors before the onset of adverse health effects.
Project Period: 09/30/2016 to 09/29/2021
Total Award: $1,845,214
Charlotte Peterson, PhD & John McCarthy, PhD (College of Medicine)
The Effects of Exercise on Satellite Cell Dynamics during Aging
National Institute on Aging
The purpose of this study is to better understand how aging and exercise affects satellite cell dynamics and the regulation of fibrosis.
Sponsor: Project Period: 01/01/2016 to 11/30/2020
Total Award: $1,751,753
Charlotte Peterson, PhD and John McCarthy, PhD (College of Medicine)
Novel Roles for Satellite Cells in Adult Skeletal Muscle Adaptation
National Institute of Arthritis & Musculoskeletal & Skin Diseases
This study will test the hypothesis that activated satellite cells are capable of repressing the synthesis of extracellular matrix components by fibroblasts through exosomal delivery of satellite cell-derived microRNAs and to determine if the increased fibrosis is responsible for limiting long-term hypertrophic growth.
Project Period: 07/27/2015 to 06/30/2020 (no cost extension)
Total Award: $1,627,725
